The Study Abstract: Therapeutic potential of curcumin in eye diseases.
Curcumin (diferuloylmethane) derived from the rhizome of Curcuma longa L. has been used for thousands of years in traditional Chinese medicine and Ayurvedic medicine in Asian countries to treat liver diseases, rheumatoid diseases, diabetes, atherosclerosis, infectious diseases and cancer. It exhibits a wide range of pharmacological properties, which include antioxidant, anti-inflammatory, antimutagenic, antimicrobial and anticancer activity. Herein the mechanisms of curcumin impact on oxidative stress, angiogenesis and inflammatory processes are described indicating that curcumin use may inhibit those pathological conditions and restore body homeostasis. Its effectiveness was also proved for major eye diseases. In this review, the influence of curcumin on eye diseases, such as glaucoma, cataract, age-related macular degeneration, diabetic retinopathy, corneal neovascularization, corneal wound healing, dry eye disease, conjunctivitis, pterygium, anterior uveitis are reported. The analysis of a number of clinical and preclinical investigations indicates that curcumin may be used as a therapeutic agent in the treatment of various eye disorders.
Source: Radomska-Leśniewska DM, Osiecka-Iwan A, Hyc A, Góźdź A, Dąbrowska AM, Skopiński P. Cent Eur J Immunol. 2019;44(2):181–189.
WHAT IT MEANS TO YOU:
According to the National Eye Institute, age-related macular degeneration (AMD) is the leading cause of vision loss in the United States. But it’s just one eye disease among many. NEI also notes that, based on projections from 2010, they expect the rates of common eye diseases like cataract to double by the year 2050. But this doesn’t mean that it’s an inevitable part of your future.
While it’s well known that the polyphenol compounds in blueberries and bilberries protect overall eyesight as well as the delicate blood vessels in the retina, curcumin is a lesser known eye health botanical. But this amazing compound derived from turmeric may also provide a first line of defense against diabetic retinopathy, conjunctivitis, AMD, and other eye conditions.
A review of preclinical and clinical studies has found that, because curcumin works along so many inflammatory pathways, it actually stops the damaging inflammation that can trigger a variety of vision problems. For example, curcumin inhibits the proinflammatory cytokines associated with dry eye syndrome, especially when it’s combined with clinically studied sea buckthorn oil.
Scientific studies have found that curcumin may also help to stop conjunctivitis, thanks in part to its anti-inflammatory and anti-allergen effects. And, in laboratory studies of AMD and diabetic neuropathy, curcumin preserved photoreceptor cells and increased levels of natural antioxidants to protect blood vessels.
The only catch is that, while curcumin has been a part of traditional medical practice in Asia for thousands of years, the compound can be difficult for the body to absorb efficiently. That is why it is important to choose curcumin that has been blended with turmeric essential oil to enhance absorption and provide ar-turmerone, an anti-inflammatory component found naturally in the oil. You may find that daily supplementation provides a preventative effect against the decline of one of life’s most precious gifts.